Due to the pandemic, aerosol pollution has come to the fore as an indicator of indoor air quality. In ESTATE, possibilities for reducing the particle concentration with regard to their energy efficiency are to be examined and combined to the greatest possible extent. Measures should be developed and profitably combined with one another based on digital technologies such as sensor networks, artificial intelligence, flow simulation and cloud-based data analysis. Improved energy efficiency at the system and component level is to be achieved through the further development of technology. The results should provide building blocks for the COVID-19 pandemic in the short term and for potential future infectious diseases that can be transmitted by aerosols in the longer term, which offer a stable level of health protection and actively promote the achievement of climate targets through CO2 savings using digitalized, energy-efficient solutions.